Oasis
I really like the sense of isolation that you get from games like FTL (an unforgiving strategy/survival space game). The isolation is somehow cold and cozy at the same time. Cold, because in space, everything is distant, resources are tight, and there is danger and death everywhere you go. You're on your own, and there's but a thin sheet of metal separating you from the infinite, suffocating void of space. And on a grander scale, there is a sense of impending, ultimate doom, as the galaxy is in turmoil and civilization seems to be going downhill.